BCS 240 Lecture Notes - Lecture 19: Ionotropic Glutamate Receptor, Choline Acetyltransferase, Vesicle Fusion

• School: University of Rochester
• Department: Brain and Cognitive Sciences
• Course: BCS 240
• Professor: Davis

Document Summary

Acetylcholine: derived from acetyl coa (from cellular respiration in the mitochondria) and choline (from diet/liver) via choline acetyltransferase (chat) Chat enzyme is manufactured in soma and transported to axon terminal (can be used as a marker for cells that use acetylcholine) packaged, transported, and released from axon terminal (standard) Ampa channel ionotropic glutamate receptor responsible for fast excita(cid:415)on permeable to both na+ and k+ (net inward/excitatory current) Nmda receptor ionotropic glutamate receptor responsible for learning and memory (in hippocampus) requires depolarization to remove the magnesium ion block (ligand-voltage gated channel) permeable to ca2+ metabotropic glutamate autoreceptors are also in presynaptic membranes (block ca2+ influx) Gabaa ionotropic gaba receptor responsible for fast inhibi(cid:415)on. Gabab metabotropic gaba autoreceptor (blocks ca2+ influx) glycine receptors are also permeable to cl- (like gaba receptors) Indolamines: tryptophan converted via enzymes into serotonin, which is converted into melatonin serotonin in cns released by gastrointes(cid:415)nal tract to move food down the esophagus to the stomach and by the.