LAB M 418 Lecture Notes - Lecture 3: Retinol Binding Protein, Transthyretin, Haptoglobin

• School: UW
• Department: Laboratory Medicine
• Course: LAB M 418
• Professor: Daniel D Bankson

Document Summary

Serum proteins: prealbumin: transthyretin, albumin [closest to anode (+) end, alpha-1 region, alpha-1 antitrypsin, alpha-2 region, alpha-2 macroglobulin, haptoglobin, ceruloplasmin, beta region, transferrin, beta-lipoprotein, complement c3, beta-2 microglobulin, note that beta-2 region is not visible, gamma region. Igg, iga, igm, crp: crp: c reactive protein. Acute phase reactants: positive, c-reactive protein, complement factors, fibrinogen, haptoglobin, alpha-2 macroglobulin, alpha-1 acid glycoprotein, ferritin, ceruloplasmin, alpha-1 anti-trypsin, negative, albumin, prealbumin, transferrin, rbp (retinol binding protein) Retinol binding protein (rbp) neg acute phase reactant: mw ~21000, forms a 1:1 copmlex with prealbumin, prevents renal excretion, synthesized in the liver. Increased in renal insufficiency: decreased in liver failure and malnutrition. Albumin neg acute phase reactant: function, a significant contributor to oncotic pressure, marker for nutritional status, liver synthetic capacity and protein-losing kidney or gi disease, binds variety of ligands, hormones, drugs, fatty acids, metal ions.