MICROM 461 Lecture Notes - Lecture 5: Malassezia, Germ Tube, Rhizopus
19 Apr 2020
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Microm 461 lecture 5: endogenous and exogenous opportunists: opportunists, organisms that can cause disease. In immunocompromised hosts: when first line defenses (skin, mucous membranes) have been breached, opportunistic infections vs. primary infections, endogenous vs. exogenous, endogenous: candida albicans and pneumocystis jirovecii, exogenous: cryptococcus, rhizopus, aspergillus. Endogenous opportunists: candida albicans, part of normal microbiota (skin, mucous membranes, can cause superficial infections and more serious disseminated infections, can have various forms: yeast, pseudohyphae, (true) hyphae. 40x, can see that pseudohyphae have pinched edges, Initially thought to be a eukaryotic parasite: two forms (parasitology terms, trophozoite (trophic) form, asexual form, predominates in lungs and causes pathology, cyst form, sexual form, larger. In culture: cannot be grown in culture, diagnosis. Based on microscopy of sputum, bal (bronchoalveolar lavage), lung biopsy. These could be cysts that have released the intracystic bodies or they could be artifacts of the staining. You can also see the structure of some collapsed cysts ( pitted olives )
