PSYCH 202 Lecture Notes - Lecture 20: Amyloid, Amyloid Beta, Neurofibrillary Tangle
Document Summary
Intense fear response, anger, flashbacks, nightmares, increased autonomic arousal, hypervigilance (inability to tune into salient stimuli), impaired memory, impaired cognition (problems with short-term memory and consolidation) Fear conditioning, intensified by stress hormones acting in amygdala. Predisposition manifested as smaller hippocampus - before trauma. Not all individuals who survive or witness trauma will develop ptsd. When trauma is experienced by many in a culture, ptsd is less common - psychosocial support and shared experience may protect against it. Anxiolytic drugs (anxiety drugs - gaba agonists) Treatment with adrenergic antagonist propanolol within 6 hours of a trauma has been found to prevent development of ptsd in some. Progresses through 5 stages characterized by loss of cognitive, emotional, motor, and basic life functions. Symptoms result from neural damage throughout the cortex, limbic system and brain stem. Disease starts in cells that should make acetylcholine. Correlated with presence of two abnormal protein accumulations. Some familial forms of ad have been identified.
