MCB 10 Lecture Notes - Lecture 10: Cystic Fibrosis, Alec Jeffreys, Genetic Drift
25 Sep 2016
School
Department
Course
Professor
Document Summary
Lecture 11 population genetics ii: genome-wide association studies, older techniques search for known gene variants, typically in only a few people. Sequencing of the human genome and the hapmap project (which identifies snps) have led to new tools for identifying genes associated with disease: genome-wide association studies between snp patterns and phenotypes in large groups of individuals. Snps single nucleotide polymorphisms; sites in a genome where the dna base varies in at least 1% of the population: a snp can be anywhere among our roughly 3. 3. billion base pairs. Population genetics the study of the genetics of a population and how the alleles vary with time: allele frequencies affect the genotype frequencies (the two homozygotes and the heterozygote in the population) Five factors can change gene frequencies: nonrandom mating, migration, genetic drift, mutation, natural selection. Phenotype frequencies frequency of a trait varies in different populations.
