NPB 101 Lecture Notes - Lecture 4: Cell Membrane, Afterhyperpolarization, Resting Potential

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Equilibrium not static, moves little in and out. Hyperpolarization = even more negative (lower than threshold. Rapid stereotyped change in em, which occurs in response to a stimulus depolarizing em to threshold. 70mv to +30mv: depolarization starts, second decrease of pna and increase pk, at the action potential peak, flow of potassium ions into the ecf restores the membrane potential to the resting state, repolarization starts. Additional characteristics: na+ channels open during depolarization by positive feedback, when the na+ channels become inactive, the channels for k+ opens. This repolarizes the membrane: as the action potential develops at one point in the plasma membrane, it regenerates an identical action potential at the next point in the membrane, therefore, it travels along the plasma membrane undiminished. Ion permeability: voltage gated na+ and k+ channels. This channels also opens with depolarization: a bit slower, has a single activation gate. Depolarization: when positive ions go into the cell making it less negative.

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