BIO SCI 93 Lecture Notes - Lecture 9: Tyrosine Kinase, Paracrine Signalling, Endomembrane System
18 Aug 2016
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BIO SCI 93 Full Course Notes
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The motor protein ___ transports cargoes toward the ___ end of the mt. The endomembrane system is a collection of membranous organelles tat compartmentalizes different function in specialized structures. Paracrine signaling: signal released only reaches to neighboring cells. Synaptic signaling: connection between neuron and target cell. Secreted signals that act at distant sites: hormones. Hormonal signaling: only affect cells that have specific receptor for hormone. Travel from one cytoplasm of one cell to cytoplasm of another. Reception occours most of the time at the cell surface. Ligand binds to receptor: induces change in shape of receptor. Receptors: plasma membrane proteins, cytoplasmic or nuclear proteins, plasma membrane receptors (gcpr) G protein moves over to bind with receptor. G protein breaks off and travels to enzyme; response triggered; ligand leaves receptor. Gtp phosphorylated; g protein becomes inactive: tyrosine kinase receptors (tkr) Two different receptors bind to different signaling molecules. Phosphate added to tyrosine amino acid; 6 phosphates.
