PSYCH 15 Lecture Notes - Lecture 17: Tricyclic Antidepressant, Diazepam, Fluoxetine
Document Summary
Symptoms: delusions, hallucinations, odd behavior, incoherent thought, inappropriate affect. Hallucinations, delusions -- especially persecutory and of grandeur, disorganized thought, bizarre behavior. Flat affect (no emotion), reduced social interaction, anhedonia (no feeling of enjoyment), avolition (less motivation, initiative, focus on tasks), alogia (speaking less) Several different chromosomes implicated -- associated with various early insults, infections, autoimmune reactions, toxins, traumatic injury, stress. Interference with normal development of susceptible individuals may lead to development of disorder (miriam dying for tita johanna) -- Chlorpromazine - calms agitated patients, activates emotionally blunt patients - no longer used. Reserpine - effective, but no longer used bc of bad side effects. Disorders of psychological function that need treatment. What chlorpromazine does: blocks dopamine receptors -- decreases activity -- effective. Therefore schizophrenia is probably caused by too much dopamine activity. Reserpine depletes brain of dopamine -- makes vesicles leaky . Amphetamine and cocaine produce psychosis (more dopamine) Haloperidol -- also blocks dopamine, but blocks d2.
