MCB 4211 Lecture Notes - Lecture 3: Natural Killer Cell, Severe Combined Immunodeficiency, Digeorge Syndrome
6 Sep 2016
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Lecture 3 page 1: sponges- can be disaggregated into single cells can be reform, from different species able to sort themselves out. Interactions of membranes to recognize self and not self: platyhelminthes worms- can recognize and attack no self. Very poor memory and specificity to response. Round worms and earthworms - slightly more specific: fish- studied immune response for aqua culture purposes, llamas- make mini antibody, durability is far higher than in humans, stable at boiling temperatures, ph. Toll like receptors (tlr"s: essential to innate immune response, pattern recognition receptors. Fork head n1: fox n1- mice with alopecia, congenital thymic aplasia. Digeorge syndrome: nsg mouse- nod scid gamma common chain. Lacks t cells, b cells, nk cells defective. Gamma common chain- receptor for many cytokines. At 20 generations reached probability to 98. 5% at any locus has reached homozygosisity, fixed as inbred.
