PNB 2265 Lecture Notes - Lecture 1: Blood Doping, Cellular Respiration, Anemia
24 Jan 2017
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Regulation - ph, osmolarity, temp (-38 degrees c), fluid loss (injury) Albumin - control osmolarity, help in transport (lipid, hormones, steroids) % of volume that has been sampled. Men vs/ women hematocrit volume should be = But men have higher because of testosterone stimulates rbc. Blood analysis: cbc (complete blood count) levels) Cbc + differential - provides info on wbc populations. Biconcave shape - no nucleus (no gene transcription etc) Rbcs contain hemoglobin (main protein in rbcs) Globins are enclosed by separate genes alpha and beta. Fetal hemoglobin has alpha and gamma chains. Each chain contains a heme group (which contain reactive iron -fe) Bohr effect - when co2 binds hb this facilitates the release of oxygen (consumed more oxygen to make. Holdane effect - deoxygenated hb has a higher affinity for co2 where hb is 50% saturated. Oxygen dissociati on curve n average, every single hb molecule have 0 o2 bound.
