PNB 2265 Lecture Notes - Lecture 4: Antibody, Liver Failure, Acute Tubular Necrosis
25 Jan 2017
School
Department
Course
Professor
Document Summary
Red blood cells survive for approximately three months inside the body before undergoing apoptosis: very controlled manner, cell that contains hemoglobin. Phagocytosis by macrophages: take cell in and break it down. Protein components: heme is converted to biliverdin, then bilirubin. Intermediate: excreted in the liver as bile. Incorporated into secretions: might end up as solid waste or be recycled. Iron (fe) component: very reactive, transported by transferrin to bone marrow. To travels safely through the bloodstream: stored in cells by ferritin. Tends to be recycled: to make the hemoglobin component, we need iron. Kidneys are efficient to quickly get rid of reactive iron so they put it in urine. Kidney damage from trying to get rid of all the blood and hemoglobin as waste. Liver failure: hemoglobinuria: hb in urine, may lead to acute tubular necrosis. Can"t get rid of this in an easy and safe way.
