PNB 2265 Lecture Notes - Lecture 9: Peanut Allergy, Autoimmune Disease, Paresthesia

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The specific response of foreign threats is both protein and cell based. Antibodies are the primary protein (b-cells) while t-cells mediate the cell based response (cid:271)oth are predi(cid:272)ated o(cid:374) k(cid:374)o(cid:449)i(cid:374)g (cid:449)hat should (cid:271)e prese(cid:374)t (cid:448)s (cid:449)hat should(cid:374)"t (cid:271)e. Operational term: anything that triggers the specific immune response is an antigen, tells you nothing about its structure or size, b/t-cells and antibodies recognize antigens. Any structure: sugar, lipid, protein, need to be large enough, can be any shape but needs to be big enough for the b/t cells and antigens can detect. A(cid:374)tige(cid:374)s are a(cid:374)ythi(cid:374)g that does(cid:374)"t (cid:271)elo(cid:374)g to your (cid:271)ody a(cid:374)d does(cid:374)"t (cid:373)at(cid:272)h a shape o(cid:374) the surface of the antibodies. Your body recognizes it as not belonging. Lymphocytes: b (bursa) lymphocytes, mature bone marrow, produce immunoglobulins, t (thymus) lymphocytes, mature in the thymus, subclasses, soluble proteins. Major histocompatibility complex: group of cell surface proteins. Mhc1 all cells except erythrocytes, recognized by t helper cells.

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