MCDB 134 Lecture Notes - Lecture 11: Measles Virus, Slamf1, Cd46
15 Nov 2017
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Document Summary
Multiplication of measle virus (similar to vsv) (-)ssrna to +mrna. H protein- protein on the virus side that bind to host and agglutinate rbc. F protein- impt for penetration (entry into cell ) Has conformational change of f protein that activate a fusion activity. Trigger the fusion between envelope of v. and cell membrane. Catalyzed by vap (l-protein with the nucleocapsid structure) Polymerase slip and add a lot of a (the poly a tail) H and f protein will go thru er and protein trafficking. Need protein n,p,m,l viral protein + pathogenesis factors: Some ribosomes bypass 1st aug and start with. So has a diff reading frame han the 1st. 5" cap-----------------------------------3" poly a made when the reading frame changes by one nucleotide, which means a different stop codon is used. b/c of polymerase slippage, a g nucleotide is inserted before the initial stop codon. Different cellar receptors are used during diff phases of infection.
