MCDB 134 Lecture Notes - Lecture 10: Integral Membrane Protein, Fucose, Transmembrane Domain
15 Nov 2017
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Release by budding cytoplasmic membrane on infected cell. Make a viral envelop (including protein that is our viral protein/ g protein) Contain a signal sequence that directs the interaction between protein being made and the er of infected cell and ribosome system that is making the protien. That got added on virus backbone is a reflection of the cell that is about to get infected. Cleave off some of the mannose and glucose. Have additional new sugar- galactose, fucose, sialic acid. Conc of viral mrna is greater than conc of cell mrna. In post-dna transcription by pol ii, pol iii inhibits dna-dependent transcription of the cell. Rabies is via saliva usually by a domestic dog outside of u. s. Pathogenesis of the disease neurotropic disease. inoculation---> bite. replication occurs at bite site. spreads to the central nervous system quickly. Before u have an immune response progression is very rapid. causes coma then death.
