MCDB 134 Lecture Notes - Lecture 14: Orbivirus, Orthoreovirus, Reoviridae
15 Nov 2017
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Depending on member, it either has double or triple capsid. Segmented (depending on family, either has 10/11/12 segments) Attachment cell receptor: sialic h+ and junction adhesion molecule viral: sigma1a. Loss of protein: sigma3, uk, sigma 1-> inner capsid shell (aka svp) 6 proteins lambda1, lambda2, lambda3 (3 is catalytic polymerase), u1, u2, sigma2 + 10 dsdna segments. Has v. a. p. resulted from the uncoating of outer capsid shell ds+- genome: 3 large, 3 medium, 4 small. +ssrna: 3l, 3m , 4s protein: lambda, u, sigma. S (small) l m s lambda u sigma conservative mechanism: sigma---> s1---> sigma1a +sigma1b +sigma1ns cell cytoplasm looks flooded with mrna while making the viral products. 5" cap with a conserved cua genes, but 3" end has no poly-a tail mrnas are efficiently expressed. 40s subunit ribosome binds near 5" end of message. 40s ribosome advance toward 3" end of message and stop when it encounters the 1st aug triplet.
