MCDB 134 Lecture Notes - Lecture 22: Reverse Transcriptase, Vpu Protein, Ribonuclease H
15 Nov 2017
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Encode number of genes not in other retrovirus that are regulatory. Gag: prgag, which produces 4 proteins (matrix, capsid and 2 nucleocapsid) Env: prenv, which produces 2 proteins (sugp120, tmgp41) Pol: prgag-pol, which produces 3 proteins (reverse transcriptase, rnaseh, **protease in hiv is made is pol not gag** Rev increase cytoplasmic concentration of unspliced and singly- spliced rna. Affect pathogenesis and inhibit cellular gene products that inhibit cell growth. Pr160env, which give rise to gp120 (su)+gp41(tm ) Viral gp120 interacts with cd4. not efficient enough for entry, but after gp120 attachment, get conformational change in gp120 that exposes other components (aka co- receptor) needed for attachment. co-receptors: chemokine receptor. Ccr5: beta receptor expressed in early stages of disease on macrophages and on pbmc (peripheral blood mononuclear cell) cells. Cxcr4: alpha receptor. expressed in late stages of disease on macrophages and on pbmc cells expressed in late stages of disease on macrophages and on pbmc cells and various other tissues.
