MCDB 134 Lecture Notes - Lecture 23: Vpu Protein, Apobec, Intravenous Therapy
15 Nov 2017
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A phosphohydrolase: enzyme that de-phosphyorylate dntp --> dn+ppp. Historically males: major cause of death is due to accidents: ~50-60/100k people mid 90s---> hiv became major cause of death females: major cause of death is cancer. Understanding how virus replicate and develop anti-viral that inhibit virus replication. Develop an inhibitor that is specific to the gene product but won"t be cytotoxic to the host. Inhibitor of reverse transcriptase to block provirus synthesis. Azt: 3" azito- 5" deoxy thymidine, which is a pyrimidine analog. Cellular kinase turns azt to azt trp phos. Inhibits protease: inhibits processing of precursor polyprotein gag-pol. If have multiple inhibiting agents, it"s more likely for it to work because virus is less likely to have all of those mutations to get around cell inhibitors. Important to be adherence: meaning to stick firmly to an hiv regime; taking medicines every day and exactly as prescribed. 180-200nm in size dsdna genome: linear and large.
