MCDB 134 Lecture Notes - Lecture 27: Interferon, Innate Immune System, Cytokine

31 views4 pages

Document Summary

T-cells: produce cytotoxic t-cells much slower in response than innate interferon response. Interferon cytokine response is non-specific against virus that caused infection and all other invading pathogens. rapid (temporally) after infection. Discovered in influenza virus infection in chick cells. When used to treat uninfected cell, it induced an antiviral state in uninfected cells. When these cells were inoculated with virus, they didn"t get infected because of antiviral response. Must bind to proper receptor on cells to trigger response. Isg (interferon stimulator gene) include protein that are antiviral, which inhibit virus growth. Process by which the interferon as a ligand, when bind to its receptor, trigger response. Jak: janus tyrosine kinase that phosphorylated stats to activate stat in cytoplasm, which is then trafficked to nucleus to bind to enhancer. Interferon treatment causes a reduction in rate of virus multiplication. Among genes induced by interferon (isg) , pkr and 25a synthetase inhibit protein synthesis.

Get access

Grade+
$40 USD/m
Billed monthly
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
10 Verified Answers
Class+
$30 USD/m
Billed monthly
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
7 Verified Answers

Related Documents

Related Questions