MCDB 134 Lecture Notes - Lecture 26: Hepatitis C Virus, Zika Fever, Dengue Virus
15 Nov 2017
School
Department
Course
Professor
Document Summary
1st isolated in 1947 in zika forest, uganda. Can progress to severe outcome such as neuro-developmental disorder. Increases miscarriage and causes microcephaly (reduced head size) of newborn because of cerebral damage. Transmitted through blood (mosquito bites), sex, and pre-natal transmission. 119 pregnant women infected with 88 birth and deficiency in. 3" end: non-structural gene products that are important in rna replication and puifease. Cellular receptors: cd81& srb (scavenger receptor b that binds to high-density lipids) Acid-mediated fusion causes release of nucleocapsid to cytoplasm. Uses ires (structure is different than picorna"s ires) Has protease activity (autoproteolysis) to make mature protein products. Need proteins that aid rna replication to make -ssrna. Template to make more +ssrna (in hepatocyte-> liver cell) Virion morphogenesis and release via er secretory pathway. Causes liver inflammation which leads to liver dysfunction (tissue damage) Not so much a problem because it"s defective and can"t replicate on its own. ** twinrix: used for hepa and hepb** hepc: ribvirin.
