PSYC 181 Lecture Notes - Lecture 5: Catalepsy, Pharmacology
Document Summary
Competitive antagonists: binds to same receptor as agonist, shift does-effect for agonist to right, effect can be overcome by sufficient dose. Noncompetitive antagonists: shift dose-effect for agonist to right, effect cannot be overcome by sufficient dose (decrease in maximum effect, ex: toxins, venoms. Once there, no way to get rid of it: agonist can only act on the population of receptors not effected by the antagonist (may be reversible or irreversible) Reversible: acts to prevent agonist-receptor coupling (on different site than. Irreversible: may form long-lasting bond with receptor agonist, through different mechanism) Tolerance and sensitization: the effects of a drug may change with repeated administration, tolerance. Higher dose required to produce original effect (shift to right) Maximum effect may also be reduced: cross-tolerance. If tolerant to one drug in a class, can become tolerant to other similar drugs: sensitization. Lower dose required to produce the original effect (shift to left) Maximum effect may increase: cross sensitization.
