PSYC 181 Lecture Notes - Lecture 5: Tail Suspension Test, Behavioural Despair Test, Startle Response
Document Summary
Evaluating the behavioral effects of drugs: secondary evaluation: tests of more specific functions (either unconditioned or conditioned (learned) Tail-flick test: turn light on and see if mouse flicks its tail. Hot plate test: turn temperature up on hot plate with mice on it; test temperature in which the mouse gets up. Used to e(cid:448)aluate drugs to i(cid:373)pro(cid:448)e (cid:373)e(cid:373)ory (cid:894)alzhei(cid:373)er"s(cid:895) a(cid:374)d as a toxicological screen for amnesic side effects. Spatial radial maze task: mouse placed in a maze with lots of spatial cues; use these cues to avoid revisiting arms (ecologically valid: all arms baited, must not revisit arms, different brain systems than non-spatial. Water maze test: use spatial cues in room to locate submerged platform: measure latency to mount platform and swim path, different brain systems than visible platform. Fear and anxiety test: augmented startle response: training: light and shock paired, testing: noise-alone trial is normal startle (in dark, testing: light and noise trial is augmented startle (in light)
