PSYC 181 Lecture Notes - Lecture 7: Synapsin, Ligand-Gated Ion Channel, Reuptake
Document Summary
Conditioned place preference: pavlovian context conditioning procedure. Pair drug administration with place in environment. Take advantage of a principle of reward. Ti(cid:373)uli that are rewardi(cid:374)g (cid:862)eli(cid:272)it approa(cid:272)h respo(cid:374)ses a(cid:374)d maintenance of (cid:272)o(cid:374)ta(cid:272)t with the sti(cid:373)ulus(cid:863) On test day: measure where spend time: advantages. Not measure drug reward but rewarding properties of secondary reinforcer. Sample question: which s(cid:272)hedule of rei(cid:374)for(cid:272)e(cid:373)e(cid:374)t is used to (cid:272)al(cid:272)ulate (cid:862)(cid:271)reakpoi(cid:374)t(cid:863): a) fr10, b) vi15, c) drl schedule, d) variable ratio, e) progressive ratio. Synaptic transmission introduction: synapses: site of action of most psychoactive drug, soma: cell body, axon, dendrite, synaptic vesicles, synaptic cleft, postsynaptic, presynaptic, glia, most drugs can act on any location listed above. Synapses: types of cell-cell junctions: tight junctions: membrane fused, gap functions: close juxtaposition (2-4 nm) or electrical synapse, chemical synapses: synaptic cleft (20-30 nm) or polarized. Multiple types of synapses: vesicle varieties. Flattened vesicles: multiple patterns of connectivity. Steps in synaptic transmission: synthesis, transport, storage, release.
