PSYC 181 Lecture Notes - Lecture 12: Benzatropine, Globus Pallidus, Pergolide
Document Summary
Making drugs more selective causes them to be less effective in treating psychosis. Look for combination that works and have low side effects: risperidone (risperdal) Approved for autism to quell violence approved for kids if they are environmental disturbances (danger to self and others/animals) violence definition is subjective and emotional regulation may not be violent, so higher proportion of autistics are being prescribed than should be: olanzapine (zyprexa) Binds to lots of dopamine and serotonin receptors. Can be given once every 2 weeks as a depot- given intravenously: quetiapine (seroquel) Blocks dopamine, serotonin, norepinephrine, and histamine receptors. Black box warning: apriprazole (abilify) marketed for bipolar mania. Abilify is commercially successful because it is approved for bipolar disorder drug itself is not very different from other atypical antipsychotics: paliperidone (invega) active metabolite of risperidone. Isolate isomer and get a new patent tin order to sell it (not really a new drug, almost identical to the one it came from)
