NTDT401 Lecture Notes - Lecture 7: Neurotransmitter, Vasoconstriction, Red Blood Cell
30 Sep 2016
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Pl and plp transported by blood to extrahepatic tissues. 1st plp needs to be hydrolyzed to pl before uptake. Plp through schiff base formation (product of amino group and aldehyde) Bonds around central c can be acted on by enzymes. Bond broken determined by enzyme (ex: decarboxylase, transaminase) Aspartic amino transferase (ast) --> aspartate donated amino group to alpha keto acid forming oaa and a different amino acid. Alanine amino transferase (alt) --> alanine donates amine group to alpha keto acid forming pyruvatd and a different amino acid. Plp removes methyl group from serine and transfer to folate (thf). 5, 10 ch2 thf and glycine are produced. Plp synthesizes heme, niacin, histamine from histadine, carnitine, taurine, dopamine, and more. Plp required for glycogen phosphorylase activity to form g-1-p. Plp reacts with lysine residues in steroid hormone receptor proteins. Pic excreted in urine and reflects recent vitamin intake.
