NTDT401 Lecture Notes - Lecture 8: Methylation, Passive Transport, Bioavailability
16 Oct 2016
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Associated to cancer, birth defects, cardiovascular health. Forms: oxidized absorbed this way, reduced forms tetrahydrofolate (thf/thfa), dihydrofolate (dhf). Up to 4h added on pteridine ring at 5, 6, 7, 8. Need reduced form to function: mono glu (folic acid) supplements, enriched grains, fortified foods. Poly glu: poly glu (folate) food and tissues. Poly to mono before absorption or crossing of cell membrane. Can"t leave the cell: single carbon attachments at the 5th or 10th location. Function: make folate longer by 1c or make it shorter used in reduced forms. 5, 10 ch2 thf and 5 ch3 thf. Bioavailability of folic acid (mono glu): 85% (synthetic form is better!) First hydrolyze food folate to mono glu form. Conjugases: digestion is dependent on this enzyme. Conjugases do the hydrolyzation from food folate to mono glu. Breaks down the peptide chain to get rid of multiple glu. Zinc and chronic alcogol injestion can diminish folate absorption.
