NTDT401 Lecture Notes - Lecture 27: Superoxide Dismutase, Sulfite Oxidase, Aldehyde Oxidase
8 Dec 2016
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Poorly absorbed - usually <5% what enhances absorption? ligands: histidine, citrate what inhibits absorption? fiber, phytate, oxalic acid, ca, p. Sod (superoxide dismutase) in mitochondria = mn-dependent. Arginase --> produces urea = mn-dependent tissues/systems affected. S/s = skin problems (scaly rash) & decreased hdl. Ai = 1. 8/2. 3 mg/d is intake a problem in the u. s. ? no! have adequate intake food sources. Yes - ul = 11 mg/d s/s of toxicity (ni?) Organically bound molybdenum active cofactor form? molybdopterin --> used in the body! Needed for metabolism of sulfur-containing aa (hcy --> met) Mo6+ mo4+ xanthine oxidase & aldehyde oxidase catalyze what reactions? hydroxylation xanthine oxidase & aldehyde oxidase are important why: breakdown of nucelotides (precursors to dna/rna) --> uric acid, play role in metabolism of drugs & toxins. Rda = 45 ug/d is usual intake of mo good? yes! food sources. Can form chelates & coordination complexes present in foods as: inorganic = +3, organic absorption.
