PSYC314 Lecture Notes - Lecture 9: Fenfluramine, Chlorpromazine, Basal Ganglia

• School: University of Delaware
• Department: Psychology
• Course: PSYC314
• Professor: Roth Eric

Document Summary

Dose response curve: reaches a point when there is no more increase in effect even if you are increasing the amount of drug administered. Antagonists and agonists are from the neurotransmitters point of view. A drug that blocks autoreceptors is an agonist because autoreceptors signal to the rest of the cell to stop producing a neurotransmitter, so by blocking it there will be no signal to stop the production. A drug that stimulates an autoreceptor is an antagonist. Typically open sodium and potassium channels excitatory: muscarinic ach receptor: metabotropic. Monoamine oxidase: enzymes that destroy monoamines (like serotonin) Mao inhibitors: serotonin agonist; destroys mao leaving more serotonin. Chlorpromazine: dopamine antagonist; blocks d2 receptors and reduces symptoms of schizophrenia. Cocaine block reuptake of dopamine, effect reward pathway, and voluntary movement (basal ganglia); blocks sodium dependent ion channels and therefore used as a topical anesthetic. Amphetamine causes release of dopamine by forcing the transporters to move in reverse.