APK 2100C Lecture Notes - Lecture 5: Hyaline Cartilage, Ossification, Diaphysis

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Document Summary

Ossification or osteogenesis- bone formation which occurs in an embryo through adolescence remodeling of bone throughout life repair of fractures. Intramembranous ossification bone forms directly within mesenchyme in layers that resemble membranes. Endochondral ossification bone forms within hyaline cartilage that replaces it all bones from base of skull down except clavicles undergo. 1: cartilage growth on epiphysis side of epiphyseal plate. 2: replacement of cartilage by bone on diaphysis side. Epiphyseal plates close in adulthood and bone replaces all the cartilage leaves epiphyseal line (bony structure) Osteoblasts- found in periosteum, add bone tissue to circumferential lamellae (b for build) Osteoclasts- remove bone from innter diaphyseal wall at about the same rate as osteoblasts build ( cla sh) Old bone keeps being destroyed with new bone forming in its place throughout the lifetime. Reasons for occuring: respond to mechanical stresses homeostasis of ca and p levels in body fluids. Released ca+2 ions enter interstitial fluid and then the blood.

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