BCH 4024 Lecture 7: L7
23 Jan 2019
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Document Summary
Illustrated by the binding of o2 to myoglobin and hemoglobin. Biological information is processed through binding interactions. Defined as any molecule that binds to binding sites on receptors, transport proteins or enzymes. Biochemists prefer to write as a dissociation reaction. Quantitative expression for mol ligand bound per mol protein as ligand increases. The saturation equation tells you the fraction of total sites that are occupied by a ligand. Heme containing proteins that reversibly bind o2. Hb and mb are both 8-helix polypeptides. Heme group lodged between helices e and f. Heme groups in hb don"t touch each other. O2 binding behavior depends on subunit interactions. Except for one edge, non polar r groups surrond heme. Multicellular organisms use capillaries and arteries to get o2 to cells. Red blood cells use hemoglobin to transport o2 from lungs to tissue and to return co2 to lungs. Muses use myoglobin to bind and to store o2 for emergency needs.
