BIOL 1344 Lecture Notes - Lecture 3: Eosinophilia, Basophil, Anticoagulant
13 Sep 2016
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Hemolytic anemia- rbcs lysis, mismatched blood transfusion. Erythroblastic anemia- immature cells [erythroblasts] come into circulation > macrocytic anemia- cells are too large. Aplastic anemia- no rbc formation due to toxins, poisons, or radiation. Nutritional anemia: lack of iron in diet. Macrocytic anemia: rbcs do not divide and enter circulation due to lack of vitamin b12. [b12 and folic acid are necessary for cell division] Pernicious anemia: lack of intrinsic factor [factor produced in stomach of person that helps absorption of vit b12 in intestines] Minor >can survive for a few years with plenty of blood transfusions. Sickle cell anemia: hemoglobin crystalized due to one amino acid substitution. Cells are not immunocompetent > immature cells, leads to lack of immunity. Migrate to site of infection, get out by diapedisis; phagocytic. Recognize proteins called selectins on surface of infected cells. Identified by fine granules and nucleus that has 3-5 or more lobes; polymorphonuclear cells. Source of heparin: natural anti-coagulant; prevents intravascular clotting.
