CHEM 233 Lecture Notes - Lecture 10: Potassium Carbonate, Paracetamol
7 Dec 2015
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Document Summary
The objective of this lab is to prepare the compound of phenacetin from acetaminophen through. Phenacetin is essentially prepared while iodoethane is in the presence of base. The hydrogen which is phenolic has enough acidity to become deprotonated from the potassium carbonate and allow reaction to occur. The product is then purified by recrystallizing and is distinguished with tlc, melting point analysis, and ir spectroscopy. The hazards that had to be recognized was that 2-butanone, ethyl acetate is quite flammable, iodoethane and methyl chloride are both toxic whereas iodoethane is quite corrosive, and sodium hydroxide could cause burns. Because of these, it was important to wear goggles and gloves at all times and to clean beakers or other glassware appropriately. The williamson ether synthesis was commonly used for ethers since the approach could apply to the basis of alcohols and alkyl halides. Two steps occur in which deprotonation of the alcohol by a strong base forms an alkoxide ion.
