PSY 312 Lecture Notes - Lecture 24: Light Therapy, Ugo Cerletti, Seasonal Affective Disorder
26 Oct 2020
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Psy 312 lecture 24 schizophrenia: da activity in schizophrenia. Side effects of antipsychotic medication: tardive dyskinesia: facial tics and gestures, due to overstimulation of da receptors in the basal ganglia in some patients. "opposite" to parkinson"s disease (understimulation of the da receptors: denervation supersensitivity phenomenon, da blockade causes a supersensitivity of da receptors, when ap drug is removed (blockade is gone) an overactivity of da receptors occurs and td symptoms results. L-dopa and amphetamine can mimic td symptoms: both are da agonists, aripiprozole (abilfy, newer medication for tx of schizophrenia. "dopamine stabilizer" that blocks da in brain areas of high da concentration but increase da in regions of low concentration. Sleep deprivation: brain differences in depression, gray matter reduction, prefrontal cortex, hippocampus, amygdala, cingulate cortex, white matter reduction. Frontal cortex fmri studies: atypical activation in frontal, cingulate, and insular cortices, amygdala.
