BIOLCHEM 415 Lecture 13: BioChem Exam 2 Lecture Notes (13-24)

• School: U of M
• Department: Biological Chemistry
• Course: BIOLCHEM 415
• Professor: Raymond Trievel

Document Summary

Glycolysis stage 1: glucose is trapped inside the cell, cleave 6-carbon compounds into 3-carbon intermediates, energy required: 2 atps. To avoid water from stepping into the rxn, which would hydrolyze. Cleavage to two 3-c sugars by aldolase: f-1,6-bp turns into dhap (ketone) and gap (aldehyde) Glycolysis stage 2 (finally - harvesting energy: gap will be converted to pyruvate, creates energy in the form of 2 atps and reduces nad+ to nadh. Exergonic oxidation of carbon 1 in gap to a carboxylic acid (-50 kj mol-1: 2. Glucose + 2 pi + 2adp + 2 nad+ 2 pyruvate + 2 atp + 2 nadh + 2 h+ + 2 h20. Aside: pay attention to names: phosphofructo name usually refers to the substrate molecule, ex. transfers a phosphate group, kinase name of the enzyme that transfers a phosphate group to the substrate.