BIOLCHEM 415 Lecture 32: Lecture32_Chapter35_Apr1_Vojtek_2016

15 views25 pages

Document Summary

Dna recombination in repair in biological processes in genetic engineering. Substitutions incorporation of an incorrect base during replication that escapes proofreading by dna polymerases: transitions: Pyrimidine to pyrimidine (e. g. c to t: transversions: purine to pyrimidine (a to c, a to t, g to c, or g to t) Pyrimidine to purine (c to a, t to a, c to g, or t to g) Breaks in one or both dna strands, which may halt dna synthesis altogether. translesion polymerases: replicate across the damage & generate a rough draft of the damaged sequence. Bases can be damaged by mutagens mutagens: chemicals that alter speci c bases after replication is complete. Reactive oxygen species, such as hydroxyl radicals, can damage dna hydroxyl radicals. H: 8-oxoguanine base pairs with adenine instead of cytosine, as a result, c is mutated to an a = a transversion mutation. A pairs with t but hypoxanthine base pairs with c.

Get access

Grade+
$40 USD/m
Billed monthly
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
10 Verified Answers
Class+
$30 USD/m
Billed monthly
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
7 Verified Answers

Related Documents

Related Questions