BIOLOGY 172 Lecture Notes - Lecture 28: Vascular Endothelial Growth Factor, Basal Lamina, Telomerase

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15 Oct 2016
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For cancer cells to go bad, they have to disrupt cell growth. For a cancer to be really dangerous, it usually needs multiple mutations. These (metastatic) can move to different part of the body and spread. S4 cancer cells don"t need growth signals to divide. It will grow even in the presence of antigrowth signals. Will not undergo apoptosis (this is a way to eliminate bad cells) Angiogenesis (tumor cells figured a way to attract blood vessels to them) Genes that are mutated usually function in one of these properties: We can divide genes into two groups: tumor suppressor genes: their normal function is to prevent cancer. For the cancer to progress, they need to be mutated so that they lose this function, thus is called (cid:498)loss of function(cid:499). 2(cid:524) oncogenes: (cid:523)when the gene is normal, it"s called proto-oncogene. When mutated, it"s called oncogene(cid:524) their normal function is to promote cell growth in a controlled called (cid:498)gain of function(cid:499). manner.

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