BIOLOGY 225 Lecture 21: Lecture 10/31 - Endocrinology III
Document Summary
Th 2-3:30pm, sat 4-5:30pm nat sci bldg rm 3065b. Signal amplified with mapkkk, mapkk, mapk in case 2. Need to memorize and understand gpcr pathway camp is second messenger. Pka relies on camp, pkg relies on cgmp. Pka dissoc from regulatory unit w help of camp. Intracellular ca2+ conc goes up from both influx from outside cell and from er(?) Know slide that has table on it with this info. Hypothalamus and pineal are at top of system. Pituitary gland controls almost everything, weighs only a gram. Up to 67 of the most powerful hormones. Hypothalamus synthesizes and secretes several neurohormones hypothalamic-pituitary portal system anterior pituitary releases hormones. First hypophysiotropin together with gnrh being isolated in 1969. 41 a. a. peptide, structurally related to urotensin-secreted by frog skin and fish urophysis. Gigantism - increased gh early in life. Acromegaly - increased gh later in life. Bone structure changes after puberty (usually doesn"t change)
