MCDB 418 Lecture Notes - Lecture 9: Leptin, Ovalbumin, Glycoprotein
Document Summary
Chemical messenger that can bind to specific receptor. More free ligand (l) or receptors (r) will increase response. Receptors can become saturated at high l. Ligands: molecule or ion bound to surface of protein by noncovalent bonds. Binders: proteins with binding sites specific for ligand. Ligand-binder interactions: weak attractions (van der waals forces) and attractions between oppositely charged ionic or polarized groups. Ligand = pos & receptor = neg + conformation fit = good fit. Specificity of receptors; only respond to select. Covalent modulation: receptor gets phosphorylated once ligand binds. Allosteric: another protein binds + changes conformation of binding site. Transport hormones in blood + distribute to target tissues. Stabilize hormone concentration in blood by acting as reservoir. No because not enough data, need to know if compound x elicited a physiological response. Isoreceptor: different receptors in different locations bind the same ligand/hormone to elicit. Spare receptor: receptors are left unused = less hormone concentration needed to elicit physiological response.