CHEN 3701 Lecture Notes - Lecture 24: Toyota Electronic Modulated Suspension, Integrin, Joule
21 Oct 2015
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90% --> f = 0. 9 when in blood stream, can use excess ligand [a] assumption. What if [a] = 10 nm or 1 nm. Plug into eqn for f ex: for [a] = 10 nm: for 1nm, kd = 0. 11 nm. -> you have to lower kd to compensate for less [a: once you stop administering the pharmaceutical, how long will it take for only. Because of its small size, unbound pharmaceutical is rapidly cleared through the kidneys. Assumeing [a] --> 0 immediately b/c cleared through kidneys. Assume that dissociation of complex yields negligible [a] (assuming no association taking place) (good approximation in blood, modest approximation in tissue) Problem 2: an antibody fragment is administered to a patient via a steady infusion into the vloodstream. Because of the antibody"s large size, you can assume it is restricted to the bloodstream: derive an analytical expression describing the dynamic concentration of antibody fragment in the blood.
