CHEN 3701 Lecture Notes - Lecture 45: Citric Acid Cycle

• School: UMN
• Department: Chemical Engineering
• Course: CHEN 3701
• Professor: Hackel Benjamin

Document Summary

8:43 am pyruvate fermentation (anaerobic) (anaerobic) ethanol + co2 (aerobic) lactate. [lactate dehydrogenase] (named for the reverse rxn) pyruvate lactate. = coenzyme a + free thiol group driven by [pyruvate dehydrogenase] Acetyl coa is transferred across the mitochondrial membrane in concert with conversion of 2 nadh to. -> purpose of this is to generate acetyl coa for the tca cycle. Chen3701_biomolecularengineering page 2 many types of carbohydrates can be fed in for glycosylationif feed fructose or manose, enter at later stage of cycle than glucose or galactose. Tca cycle (aka tricarboxylic cycle, krebs cycle, citric acid cycle) -> provide electrons (nadh, fadh2) for the electron transport chain & biosynthesis (redox and other) -> supply intermediate metabolites (e. g. for amino acid synthesis, etc. ) Respiration in mitochondria: not in direct electron path as we bind 2 protons to coenzyme q, we can push 4 protons across the membrane (from matrix side to intermembrane space)