NSCI 4100 Lecture Notes - Lecture 20: Gamma Secretase, Neural Crest, Cell Adhesion Molecule

• School: UMN
• Department: Neuroscience Department
• Course: NSCI 4100
• Professor: Steven McLoon

Document Summary

3 waves of migration: 1: ventral-medial, autonomic ganglia, 2: sensory ganglia, 3: melanocytes. 3 steps of adhesion-dependent movement: extension: lamellipodia/filopodia, attachment: cam/ecm substrate, adhesion, cell adhesion molecules (cams): integrins and selectins, can bind homo/heterophillic, contraction. Guidance molecules: attract or repel, netrins+dcc, slit+robo, semaphorins+plexin/neruopilin, ephrins+ephs, chemokines and neurotrophins. Epithelial-to-mesenchymal transformation (emt: delamination of neural crest cells from neural tube, process, cells in neuroepithelium are held together by tight junctions consisting of. Integrins: alpha and beta sub (24 combos, transmembrane. Interact with actin cytoskeleton via actin binding proteins: bind rgd sequence in fibronectin, but none bind to all of them (determined by side chains, receptor for binding to fibronectin. Initiation, polymerization, stability and interactions controlled by microtubule associated proteins (maps: ena/vasp proteins: enriched in filipodia, needed for axon extension, dynein walks toward minus ends, pushing plus ends outward. Substrate adhesion: adhesion receptors, cadherin, cam.