PLPA 2003 Lecture Notes - Lecture 4: Glucose-6-Phosphate Dehydrogenase Deficiency, Red Blood Cell, Hemoglobin
Document Summary
Plasmodium genus (4 species: falciparum (deadliest, vivax (moderate, ovale & malariae (relatively mild, blood-borne disease vectored by anopheles mosquito. 584k deaths: 65% under 5 yo, 85% to 90 in sub-saharan africa, types of malaria (plasmodium falciparum) billion in economic losses to africa. Recurrent fever every 2- 3 days: ague . Can cause continual relapses without treatment (years or months later) Respiratory distress, encephalitis (cerebral malaria), circulatory collapse. Genetics review: what is the likelihood of two individuals that each carry one copy of the sickle cell allele (a recessive trait ie. sa) of having a child that has sickle celled anemia (ss), 0% b. A ected people (2 alleles) have shorter lifespans. Carriers (1 allele) have greater tolerance to malaria. Ss full sickle (die), as carrier (longer), aa normal. Innate genetic resistance to malaria: genetic blood disorders which confer improved resistance to malaria. Improved resistance: makes host resistant to p. vivax.
