CHEM 2320 Lecture 18: CHEM2320.001.02.15.17
25 Feb 2017
School
Department
Course
Professor
Lecture #18 02.15 . 2017
Cont . of "alkylation without rearrangement
I
¥
Hao
PJIC
Only work
when ketone
is at the
benzylic position ,
next to benzene
ring .
1. Need to Alkuiate .
2. Reduce .
At benzylic position , can Use H2/pdK reagent .
Other ways to reduce ketone to CHZ
Dckmmensen reduction
Znc Hg )
←tainmcalgam (mixture )
HCI
under
acidic
Wolff -Kishinev reduction
hydrazine
H2N=VH2,
OH
.
,a
basic
conditions
Use depending on what other fwnc .groups are present .
i. e
. if wanted to reduce ketone next to Alkehe ,can Use H2/Pdk .
however ,using the other two reagents will prevent alkenes from hydrogenating .
chapter 76
reactions of substituted benzenes
Naming of multiple -substituted benzenes
DRelative positions of two groups .
Learn the terms .
Look for the parent
molecule .
(1,2 )(1,3 )(1,4 )
Document Summary
Only when is at benzylic next to ring . position work ketone the position , benzene. Use depending on what other fwnc groups are present: e if wanted to reduce ketone next to. H2/pdk . however using the other two reagents will prevent alkenes from hydrogenating . Relative positions of reactions of substituted benzenes two groups . chapter. Look for the parent molecule ( 1,2 ) ( 1,3 ) ( 1,4 ) The parent is described first it"s either one for or which the name is known. The one that comes first in the alphabet. Recognize which part of the substituted benzene will be described first. That encounter a situation in which have a poly substituted benzene that may have two or more substituent may be part of the parent. List part of the parent . them all separately. Ortho , meta para because they describe position. The parent will either be benzene or one of the substituent.
