BCH 369 Lecture Notes - Lecture 12: Protein Kinase B, Chymotrypsin, Membrane Potential
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Why won"t kt gothrough nat channel and vice versa. Resolution ofcrystalstructures someare4saoresolution 2. 811 1. 6a whydo some crystals yield. 1611 resolution and other crystals only 4sf resolution howgood theoteinis an electrondensity. Crystal imperfections reduce resolution structureof a kt channel. Obtaining crystals of kt channel proteins was verydifficult. In the 90 s thegenomes of many bacteria were and more kt channels wereidentified a poor crystal sequenced. Limited proteolysis chymotrypsin was added of the kscakt channel. The kt channel was bound to antibody fragmentand crystallized. How do the tht wat ca"t channels distinguish their spear"s. Change in membrane potential along a neuron that travels. When an axon of a neuron sstimulated nat channels open altering themembrane"s electrical potential. Thistriggers theopening of a nearby voltage gated kt channel which to its original returnsthe potential state and stimulates other nut channels farther along the neuron.
