NEU 365T Lecture Notes - Lecture 15: Mood Disorder, Stimulant, Psychoticism
Document Summary
Prefrontal cortex - working memory & schizophrenia fmri studies - blood flow (correlated to activity levels) Healthy individuals - increased activity in pfc during wcst. Schizophrenic patients - selective deficits in the activation of pfc. Psychosis - mental state characterized by loss of contact with reality or gross disruption of the ability of an individual to understand the external world. Stems from the disturbance of working memory mediated by pfc. May be associated w/ gross cognitive impairment caused by advanced cases of. Schizophrenia - most common cause of chronic psychoses (~1% of the population) Characterized - loss of contact w/ reality & a disruption of thought, perception, mood, motivation, and movement. Typically becomes evident during adolescence or early adulthood. Individuals w/ mood disorders - exhibit psychotic symptoms (usually episodie & resolve w/ improvement in mood) New mental phenomena that unaffected people normally do not experience (i. e. hallucinations & delusions: negative symptoms. Amotivation - difficulty in initiating goal-directed behavior.
