NEU 365W Lecture Notes - Lecture 8: Drug Paraphernalia, Psilocybin Mushroom, Ketamine
Document Summary
Low harm to users and others, don"t cause physical dependence, not used as frequently. Old uses for hallucinogens throughout the world. Magic mushrooms - glossin - cia funded his research. Crowdsourced data about experiences - erowid"s experience vaults. 3 classes of hallucinogens - based on modes of action. Phencyclidine (animal tranquilizer) = pcp/angel dust, crystal - first one used. Analgesic effects strange dreams when emerge (feel. Sometimes sold as (but is not): delta9-thc or ecstasy. Low dose alcohol like effect (disinhibition, incoordination) Moderate/higher doses distortion of space & time, psychotic. Nmda receptors are important for memory reactions (panic, agitation, depression, paranoia) Blocks nmda receptors - are important for memory. Model of acute schizophrenia (can last 1-7 days) Self-administered in animals (to point of intoxication) Not all hallucinogens are self-administered (measure of addiction liability) Binds to part of nmda glutamate receptor (site inside channel to block it) inhibits allosterically. No known endogenous ligand for this binding site.
