NEU 365W Lecture Notes - Lecture 14: Tetrahydrocannabinol, Dystonia, Peripheral Neuropathy
Document Summary
1964 - main psychoactive constituent delta9-thc (tetrahydro cannabinol) discovered. 1984 delta9-thc thought to inhibit adenylyl cyclase. 1990 receptors mapped (cb1 main one cloned) 1993 second receptor cloned (cb2) found mainly in periphery and not brain. 1994 first antagonist developed as appetite suppressant (failed due to psychiatric side effects) 1995 precipitated withdrawal (described characteristic withdrawal: 1996 medical use legalized in ca and az. 1998 receptor knockout mice studied in opioid, cannabinoid addiction and feeding. 1753 carl linnaeus (aromatic cane used to make rope) named cannabis sativa. 1785 lamarck argued second species cannabis indica with psychoactive properties (used for religious ceremonies) more thc/psychoactive component. 1924 3 rd species cannabis ruderalis found in russia (less potent than indica: genus name cannabis generally used with terms. Hemp (lower thc) vs marijuana (high psychoactive version) described based on intended use. Marijuana in europe = skunk : origins of name: chinese character for hemp (ma) hemp seed flower. Constituents of cannabis: >90 cannabinoids produced from cannabis.
