NEU 365W Lecture Notes - Lecture 17: Nicotinic Acetylcholine Receptor, Nicotine Withdrawal, Nicotine Patch
Document Summary
04/21 lecture 17 notes: hot topic habenular and striatal activity during performance feedback and differentially linked with state-like and trait-like aspects of tobacco use disorders. Tobacco use prevalence: world: < 10% - 40% (1. 1billion people) more than half will die of a smoking related, leading cause of avoidable disease and premature death disease, damaging to every organ system in the body. E-cigarette use: us: 9%- 46, skyrocketed in younger generations can lead to new generation of people addicted to nicotine. Nicotine responsible for addiction: causes the acute psychopharmacological properties of tobacco. Stimulates midbrain da neurons that project primarily to the striatal and prefrontal regions through its agonist effects on nicotinic acetylcholine receptors. Primarily act at alpha4-beta2 receptors & other nicotinic acetylcholine receptors like alpha7: acute nicotine induces da release positively reinforcing (promotes continued drug seeking and taking) Chronic neuroplastic alterations within the circuits induce conditional dependence (shift towards negative reinforcement avoid withdrawal)
