BIOLOGY 253 Lecture Notes - Lecture 9: Spindle Apparatus, G1 Phase, G2 Phase

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G0-quiescent, no preparing to divided, most of body. 1. cell that synthesizes ecm in animal tissues: involved in wound healing, most common cell type in connective tissue. Cell cycle control: embryonic development, wound healing, replace old/damaged cells. Reasons for doing cell cycle control: maintain proper cell size, embryonic development: completion of specific developmental programs, loss of cell cycle control=cancer. In adult, cells divide when they are needed. Cdk (cyclin dependent kinase: phosphorylate things, can turn things on and off) Cdk substrates initiate all aspects of cell cycle. Cdk active during mitosis and not active during interphase, concentration is constant throughout interphase and mitosis. Ubiquitination of cyclin turns off cdk (by apc, anaphase promoting factor) *cyclin binds to cdk and now we have a complex but that complex is inactive. Cdk-activating kinase (cak): converts to adp and pi and adds a phosphate to the active site of cdk. When they form a complex, the enzyme cak is present.

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