BIOL 1106 Lecture Notes - Lecture 17: Antimicrobial Peptides, Adaptive Immune System, Innate Immune System
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BIOL 1106 Full Course Notes
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Document Summary
Introduction: body"s defenses are integrated, distinguish self from non-self invaders (pathogens, adaptive immunity. Innate immunity overview: physical and chemical barrier to pathogen entry, recognition of pathogens by receptors, cytokines attract immune cells, complement forms mac, adaptive immune system is signaled. Barriers to infection: skin, oil and sweat with lysozymes, antimicrobial peptides, beneficial bacteria and fungi, three other potential routes of injection, digestive tract, respiratory tract, urogenital tract. Innate immunity receptors: signal transduction pathway coordinated response, cytokines: interferons, antimicrobial peptides: defensins, complement: mac. Increased permeability of capillaries: chemical alarm systems activated by injury or infection, vasodilation, cell recruitment, cytokine release, fever, five hallmarks of inflammation, heat, redness, swelling, pain, possible loss of function. Organ support & the immune system: primary lymphoid organs, bone marrow b cells, thymus t cells, secondary lymphoid organs, lymph nodes, spleen, mucosa-associated lymphoid tissue (malt) Lymphocytes: b cells, antibodies (immunoglobulins, humoral immunity, t cells, cell-mediated immunity.
