E62 BME 140 Lecture Notes - Lecture 6: Protein Structure, Microtubule, Gene Expression
28 Dec 2015
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Receptor proteins: accept intercellular signals that are transmitted by hormones. Immuno proteins: recognize and bind foe molecules and friendly molecules. Structural proteins: form , girders, microtubules, fibrils, hair, silk and protective coatings. Proteins are responsible for shuttling electrons down the electron transport chain. Form follows function: protein function is determined by its three-dimensional structure. The structure of a protein determines its function. Generally the physico-chemical and geometric properties of protein surfaces determine specificity or protein activity. Internal organization and protein architecture help fix the surface. Proteins of similar overall structure can perform very different functions. Function is only a loose determinant of structure - especially if the molecule that interacts with the protein is small. Anfinsen"s rule: structure of a folded protein is entirely defined by its amino acid sequence. Sanger showed that the sequence of amino acid residues (a residue is the protein of a free amino acid that remains after polymerization) is unique for each protein.
